Prostate

Published by Andy LoCascio at July 6, 2018

Prostate Cancer

November, 2022 Prostate cancer: Zapping metastatic tumors with radiation improves survival
https://www.health.harvard.edu/blog/prostate-cancer-zapping-metastatic-tumors-with-radiation-improves-survival-202211072843

November 8, 2022 Health Beat: First-of-its-kind prostate cancer surgery through bladder
https://www.wfmz.com/health/health-beat/health-beat-first-of-its-kind-prostate-cancer-surgery-through-bladder/article_3cb09f2e-5f9c-11ed-8092-6743877da446.html

November, 2022 Developing therapies for treatment-resistant prostate cancer
https://www.sciencedaily.com/releases/2022/11/221102135650.htm

November, 2022 FDA Approves Leuprolide Acetate Injection for Advanced Prostate Cancer
https://www.targetedonc.com/view/fda-approves-leuprolide-acetate-injection-for-advanced-prostate-cancer

November, 2022 FDA Greenlights Leuprolide Acetate Injection for Palliative Treatment in Advanced Prostate Cancer
https://www.onclive.com/view/fda-greenlights-leuprolide-acetate-injection-for-palliative-treatment-in-advanced-prostate-cancer

November, 2022 Israeli Researchers use breakthrough tech to treat prostrate cancer for the first time
https://nocamels.com/2022/06/israeli-researchers-use-breakthrough-tech-to-treat-prostate-cancer-for-first-time/

November, 2022 City of Hope, in collaboration with the National Cancer Institute, is conducting a Phase 2 trial to further evaluate the use of a white button mushroom supplement to reduce PSA levels in patients with prostate cancer.
https://www.cityofhope.org/new-treatment-possibilities-and-superior-outcomes-patients-prostate-cancer

Detection of rare prostate cancer cells in human urine offers prospect of non-invasive diagnosis
https://www.nature.com/articles/s41598-022-21656-9

UTSW study suggests combination therapy might help prostate cancer patients overcome resistance to current treatments
https://www.utsouthwestern.edu/newsroom/articles/year-2022/october-prostate-cancer-cells.html

Overview of Prostate Cancer

Prostate cancer is cancer that begins in the walnut-sized gland, located beneath the bladder in the male reproductive system that makes most of the semen that carries sperm. Prostate cancer is one of the most common cancers in the United States. There are several types of cells in the prostate, but nearly all prostate cancers start in the gland cells. This kind of cancer is known as adenocarcinoma and makes up over 95% of diagnosed prostate cancers.

Prostate cancers usually grow slowly, but fast growing types exist that require immediate and aggressive treatment. Treatments include expectant management (watchful waiting) or active surveillance, surgery, radiation treatment, cryosurgery, hormone therapy, chemotherapy and vaccine treatment.

Treatments for Prostate Cancer

Treatments for Prostate cancer include active surveillance, surgery, chemotherapy, radiation therapy, hormone therapy, and targeted therapies in clinical trials.

Active surveillance: “watch and wait” is an option for men who decide not to undergo immediate surgery or radiation therapy. During active surveillance, prostate cancer is carefully monitored for signs of progression. A PSA blood test and digital rectal exam (DRE) are administered periodically, along with repeat biopsies of the prostate. Treatment commences If symptoms develop, or if tests indicate the cancer is growing.

Surgery: a surgical approach to treating prostate cancer will remove all or part of the prostate. Typically, men with early-stage disease or cancer that’s confined to the prostate will undergo radical prostatectomy-removal of the entire prostate gland and surrounding tissue. Other surgical approaches may include nerve-sparing and laparoscopic procedures.

Chemotherapy: chemotherapy alone or in combination is often part of prostate treatment plans. Several agents are approved for use in prostate cancer, including Taxotere, estramustine and mitoxantrone. Estramustine is an oral medication with hormonal and chemotherapeutic properties that has anti-cancer activity that is often combined with other chemotherapies. Mitoxantrone (Novatrone) is a chemotherapy agent given intravenously and is known to delay and reduce pain from prostate cancer metastasis.

Radiation therapy: external beam radiation, intensity-modulated radiation therapy (IMRT), brachytherapy, (radioactive seed implants), or proton therapy is often used to stop the growth of prostate cancer, sometimes in combination with surgery or chemotherapy.

Hormone therapy: the goal of hormone therapy is to prevent prostate cancer cells from using testosterone to grow. Androgen deprivation therapy shots, anti-androgen pills, or orchiectomy (the removal of the testicles) are sometimes part of the prostate treatment plan.

Targeted therapies and immune therapies: combination treatments are being tested to study vaccines, such as Provenge, and drugs such as Xofigo and Zytiga for advanced stage prostate cancers.

Clinical Trials for Prostate Cancer

National Cancer Institute Prostate Cancer Trials
http://www.cancer.gov/clinicaltrials/featured/types/prostate-cancer

Prostate Cancer Foundation: Clinical Trials
http://www.pcf.org/site/c.leJRIROrEpH/b.5849073/k.9B21/Clinical_Trials.htm

The Prostate Trial Clinical Trial Consortium
http://pcctc.org/

Center Watch: Prostate Cancer Clinical Trials by State
https://www.centerwatch.com/clinical-trials/listings/condition/36/prostate-cancer

Additional Educational Resources for Prostate Cancer

Us Too Prostate Cancer Online Resources: US TOO is an independent network of support group chapters for men with prostate cancer and their families. US TOO groups offer fellowship, peer counseling, and education about treatment options.
http://www.ustoo.org/

CancerNet : An NCI sponsored comprehensive source of cancer information including types of cancer, treatment options, clinical trials, genetics, coping, support, resources, and cancer literature.
http://cancernet.nci.nih.gov/

Treatment options for early stage prostate cancer: prostate cancer educational booklet from the National Cancer Institutes
http://www.cancer.gov/cancertopics/treatment/prostate/prostate-cancer-treatment-choices.pdf

Report to the Nation on Prostate Cancer: A guide for men and their families: Peter Carrol, MD, The Johns Hopkins University, Anthony Zeitman, MD, Harvard Medical School, Jason Rothaermel, The Cleveland Clinic
http://www.pcf.org/atf/cf/%7B7c77d6a2-5859-4d60-af47-132fd0f85892%7D/REPORT_TO_NATION_GUIDE.PDF

The American Prostate Society : The American Prostate Society is a nonprofit organization dedicated to increasing education, awareness, and service to the prostate cancer community.
www.ameripros.org

CaP Cure (The Association for the Cure of Cancer of the Prostate): Founded by Michael Milken in 1993, CaP CURE identifies and supports prostate cancer research to improve treatments and cures.
www.capcure.org

National Association for Continence : The National Association for Continence (NAFC) is a nonprofit organization dedicated to improving the quality of life for people with incontinence. NAFC publishes a quarterly newsletter, resource guide of products and services for incontinence, audio/visual programs, and other educational materials.
www.nafc.org

National Prostate Cancer Coalition: National Prostate Cancer Coalition is an organization dedicated to bringing together and representing the interests of multiple organizations and individuals with an interest in the prevention and the cure of prostate cancer through funding prostate cancer research.
www.pcacoalition.org/

Prostate cancer resources from Cancer Care: The American Cancer Society has many national and local programs to help cancer patients with travel, lodging, and emotional support.
www.cancer.org

CanSearch: Online Guide to Cancer Resources Service of the National Coalition for Cancer Survivorship that leads you step-by-step through an online search.
www.cansearch.org/canserch/canserch.htm

OncoLink: OncoLink was founded in 1994 by University of Pennsylvania cancer specialists to help cancer patients, families, healthcare professionals and the general public get accurate cancer-related information at no charge.
www.oncolink.org/disease/pancreas/

ACOR (Association of Cancer Online Resources) hosts cancer discussion groups.
www.acor.org

Oncologists Steve Strum and Mark C. Scholz’s Prostate Cancer Research Institute
http://prostate-cancer.org/