Liver Cancer: Warning signs and questions to ask your physician.
Common Symptoms Of Liver Cancer:
Questions To Ask Your Doctor:
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The liver is the organ in the body that is essential for the digestion of food. It filters blood from the intestines, processes nutrients and removes toxins. It also helps maintain the proper blood sugar levels in the body and produces some of the body’s blood clotting factors.
Liver cancer is the growth and spread of unhealthy cells in the liver. The most common form (80%) of liver cancer is called Hepatocellular Carcinoma (HCC). It begins in the hepatocytes, the main type of liver cell. HCC can have different growth patterns. The most common pattern in the United States is a tentacle-like growth through the liver, although some start as a single tumor that spreads to other parts of the liver.
Other subtypes of primary liver cancer:
Bile duct cancer (cholangiocarcinoma), which accounts for10-20% of liver cancer cases, starts in the small tubes that carry the bile made in the liver to the gallbladder, and in the bile ducts that carry bile from the gallbladder to the intestines.
Angiosarcoma and Hemangiosarcomas, which account for 1% of liver cancer patients, are fast growing cancers that originate in the blood vessels of the liver.
It is common for other types of cancers such as colon, stomach, pancreatic, breast or lung cancer to metastasize to the liver. This is not considered primary liver cancer and these liver tumors are treated with regard to their point of origin in the body, not as primary liver cancer.
Treatment options if the cancer has not spread and the rest of the liver is healthy are:
Transplant: replacement of the liver
Surgery: removal of the tumor from the liver (partial hepatectomy)
Other treatment options if transplant and surgery are not possible include:
Cryosurgery: Cryosurgery uses a metal probe to freeze and destroy cancer cells.
Radiofrequency Ablation uses a special probe to destroy cancer cells with heat.
Ethanol Injection: Ethanol alcohol is injected directly into the liver tumor to destroy cancer cells.
Chemotherapy or Chemoembolization: Chemotherapy drugs may be used to destroy cancer cells. In some cases, the chemotherapy can be directly injected into the liver tumor.
Radiation Therapy: Radiation uses high-energy X-rays to destroy cancer cells.
Anti-angiogenesis therapy: these treatments are focused on stopping angiogenesis, which is the process of making new blood vessels. The goal is to deprive the tumor of blood and nutrients in order to arrest tumor growth. The anti-angiogenesis drug Sorafenib (Nexavar) Sorafenib is one oral medication FDA approved for use in advance cases of hepatocellular carcinoma.Bevacizumab (Avastin®) is another anti blood vessel growth agent being studied for use against liver cancer.
Other targeted treatments that are in clinical studies include Menatetrenone, a drug that is chemically similar to Vitamin K, and linifanib, tivantinib, and brivanib, which work by slowing the growth of tumor blood vessels.
Another targeted therapy option may be Erlotinib (Tarceva®), which targets a protein called EGFR on cancer cells.
Virus therapy: Virus therapy works by exploiting a genetic mutation inside cancer cells that does not exist in normal cells. The mutation allows the virus to enter tumor cells and produce thousands of copies of itself.
Eventually, the cancer cells bursts, releasing the virus particles, which in turn will infect other cancer cells. One virus treatment for liver cancer is called JX-594, and uses an altered virus to stimulate the patients’ own immune response to destroy the liver cancer.
ClinicalTrials.gov: Carcinoma, Hepatocellular(National Institutes of Health)
ClinicalTrials.gov: Hepatoblastoma(National Institutes of Health)
ClinicalTrials.gov: Liver Neoplasms(National Institutes of Health)
Liver Cancer Clinical Research Trials
Center for Information and Study on Clinical Research Participation (CISCRP). CISCRP offers an online clinical trials search engine at SearchClinicalTrials.org. In addition, they provide a toll-free number where patients can receive help locating a clinical trial.
Centerwatch This site helps people connect with clinical trials by offering a list of institutional review board (IRB)-approved clinical trials.
ClinicalTrials.gov This database of publicly and privately supported clinical trials is maintained by the National Library of Medicine at the NIH.
Coalition of Cancer Cooperative Groups This organization provides resources and information in order for patients to search for clinical trials.
EmergingMed Navigator- This organization helps to identify clinical trial options that match a patient’s specific diagnosis, stage and treatment history. Clinical trial specialists can also provide telephone support to help connect eligible patients with IRB-approved study sites that are enrolling new participants.
WHO International Clinical Trials Registry Platform Search Portal The World Health Organization (WHO) coordinates health matters within the United Nations. This database allows people to search clinical trial registration information from many countries’ registries.
Adult Primary Liver Cancer (PDQ): Treatment(National Cancer Institute) Also available in Spanish
National Cancer Institute
Cryosurgery in Cancer Treatment: Questions and Answers(National Cancer Institute)
Cryotherapy(Radiological Society of North America, American College of Radiology) Also available in Spanish
How Is Liver Cancer Treated?(American Cancer Society)
Interventional Radiology Treatments for Liver Cancer (Society of Interventional Radiology)
Radiation Therapy (CanLiv)
Radiofrequency Ablation of Liver Tumors (Radiological Society of North America, American College of Radiology)
New technology to help treat liver cancer
American Liver Foundation Launch Clinical Trial Matching Tool to Accelerate Liver Disease Research
Liver Cancer Vaccine results announced in Mongolia:
June 24, 2014
Liver Cancer Vaccine Effective in Mice
Cancer Support Community
Imerman Angels One-On-One Cancer Support
Daily Strength Online Support Group
Fighting Chance- free counseling service for cancer patients and caregivers