[vc_row top_margin=”none” el_position=”first”] [vc_column top_margin=”none” width=”1/2″] [mc_small_slider id=”small_slider” images=”2773,2772″ lightbox_icon_color=”blue_light” features_images_loop=”1″ autoplay=”0″ pause_on_hover=”1″ scroll=”1″ effect=”scroll” easing=”easeinoutquint” duration=”750″ top_margin=”page_margin_top_section” el_position=”first last”] [/vc_column] [vc_column top_margin=”none” width=”1/2″] [mc_small_slider id=”small_slider” images=”2771,2770″ lightbox_icon_color=”blue_light” features_images_loop=”1″ autoplay=”0″ pause_on_hover=”1″ scroll=”1″ effect=”scroll” easing=”easeinoutquint” duration=”750″ top_margin=”page_margin_top_section” el_position=”first last”] [/vc_column] [/vc_row] [vc_row top_margin=”page_margin_top” el_position=”last”] [vc_column top_margin=”none”] [vc_accordion top_margin=”none” active=”1″ el_position=”first last”] [vc_accordion_tab title=”Colorectal Cancer Overview” tab_id=”1407556239-1-73″] [vc_column_text el_position=”first last”]
Colorectal Cancer is the combined term for two types of cancer, colon cancer and rectal cancer (the last several inches of the colon), and is often referred to as colon cancer. Colon cancer develops in the tissues of the large intestine, the lower part of your digestive system. Most cases of colon cancer originate as small clusters of cells called polyps which become malignant over time. In later stages of the disease, cancerous cells may penetrate the colon wall and spread (metastasize) to nearby lymph nodes or surrounding organs.
Polyps may be small and produce few, if any, symptoms. For this reason, doctors recommend regular screening tests to help prevent colon cancer by identifying polyps before they become colon cancer.
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Very early cancer on the innermost layer of the intestine.
Treatment of stage 0 may include the following types of surgery:
- Local excision or simple polypectomy
- Resection /anastomosis (performed when the tumor is too large to remove by local excision)
Cancer is present in the inner layer of the colon.
Treatment of stage I is commonly resection/anastomosis
Cancer has spread through the wall of the colon.
Treatment of stage II colon cancer may include the following:
- Chemotherapy and/or radiation therapy
- Targeted therapies: angiogenesis inhibitors, which act by blocking tumor blood vessel formation, and monoclonal antibodies, which target proteins on the surface of cancer cells to kill or block their growth
Cancer has spread to the lymph nodes.
Treatment of stage III colon cancer may include the following:
- Resection/anastomosis with chemotherapy
- Chemotherapy, radiation therapy
Cancer has spread to other organs outside the colon.
Treatment of stage IV and recurrent colon cancer may include the following:
- Radiation therapy and/or chemotherapy
- Clinical trials of chemotherapy, or biologic therapy after surgery
- Targeted biologic therapies
Special treatments of cancer that has spread to or recurred in the liver may include the following:
- Chemotherapy followed by resection
- Radiofrequency ablation or cryosurgery
- Clinical trials of hepatic chemoembolization with radiation therapy
- Targeted biologic therapies
(Approved chemotherapy treatment agents for colon cancer include irinotecan, Oxaliplatin, Capecitabine, and 5-fluorouracil, and monoclonal antibodies, including Cetuximab (Erbitux), Panitumumab (Vectibix), Bevacizumab (Avastin), and Regorafenib may be used alone or in combination with chemotherapy agents.)
Common Treatment Programs include:
Capox or Xelox:
Capecitabine (Xeloda) plus Oxaliplatin (Eloxatin)
5-FU, Irinotecan (Camptosar) and Leaucovorin
5-FU, Irinotecan (Camptosar) and Leucovorin
These regimens may be also combined with targeted therapies such as Bevacizumab (Avastin®), Cetuximab (Erbitux®), ziv-aflibercept (Zaltrap®)
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National Cancer Institute Colon Cancer clinical trials
Colon Cancer Alliance Clinical Trial matching Service
US National Institutes of Health
Cancer Research Institute
Center for Information and Study on Clinical Research Participation (CISCRP). CISCRP offers an online clinical trials search engine at SearchClinicalTrials.org. In addition, they provide a toll-free number where patients can receive help locating a clinical trial.
Centerwatch This site helps people connect with clinical trials by offering a list of institutional review board (IRB)-approved clinical trials.
ClinicalTrials.gov This database of publicly and privately supported clinical trials is maintained by the National Library of Medicine at the NIH.
Coalition of Cancer Cooperative Groups This organization provides resources and information in order for patients to search for clinical trials.
WHO International Clinical Trials Registry Platform Search Portal The World Health Organization (WHO) coordinates health matters within the United Nations. This database allows people to search clinical trial registration information from many countries’ registries.
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For support, including counseling, financial assistance, and community programs, as well as podcasts and publications about Colorectal Cancer:
National Cancer Institute Educational Pages
Colon Cancer Information from Live Strong
ASCO Colorectal Cancer Info
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Two types of bacteria commonly found in the gut work together to fuel the growth of colon tumors, according to a new study published in the journal Science.
February 1, 2018
Colorectal cancer: New, less toxic drug target uncovered
Efficacy And Safety of Bevacizumab in metastatic colorectal cancer: pooled analysis from seven randomized controlled trials
Bevacizumab Efficacy and Safety in mCRC: Pooled Analysis
For Advanced colorectal cancer: Promising response to new combination therapy of vermurafenib, cetuximab and irinotecan.by patients with metastatic colon cancer
First line therapy approved for Stage IV Colon Cancer
June 16, 2014
ASCO 2014: Chemo with either Avastin or Erbitux are equally effective against colorectal cancer (KRAS wild type)
Colon Cancer Drug Pricing
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Colon Cancer Alliance (Patient Advocacy Group) Monthly Patient Webnars from Fight Colorectal Cancer
Colon Cancer Buddy Program (peer-to-peer support for newly diagnosed colorectal patients)
Fight Colon Cancer
Daily Strength (Online Support Group)
Colorectal Cancer Network (not for profit foundation that offers information about colorectal cancer symptoms, treatment, and support for patients)
Susie’s Colon Cancer Foundation
Cancer Care: free counseling, support groups, education, financial assistance, online, telephone and in person support groups led by oncology social workers
Fighting Chance- free counseling service for cancer patients and caregivers
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